Polyoxaesters

A new class of hydrophilic absorbable polyesters called polyoxaesters is an excellent choice for a broad range of biomedical applications.

 

Polyoxaester development is based on aliphatic diacids possessing oxygen atoms adjacent to their α-carbons. These diacids are then polymerized in conjunction with a diol by means of a polycondensation reaction. Since organic chemists have used the term ‘oxa’ to designate the replacement of an ethylene group by an oxygen atom, these diacids have been called oxadiacids, and the resulting polymers polyoxaesters.

Strategic placement of glycolic acid moieties in the polymeric chains allow control of their hydrophobic/hydrophilic properties and of their degradation/absorption rate. Fully controllable hydrolysis and degradation profiles can be obtained by using a combination of difunctionalized aromatic compounds, such as the blend of two or more functionalized compounds made from any two or more of the glycolide, lactide, dioxanone, and polydioxanone species combined with one aromatic compound.

To learn more about polyoxaesters, view a presentation or read a mini-review article published in Polymer International.

Range of Applications

 

  • Suture Material
  • Mesh
  • Absorbable Elastomer
  • Adhesion Prevention
  • Sealants & Adhesives
  • Drug Delivery
  • Wound Coverings
  • Tissue Sealants & Adhesives
  • Tissue Engineering
  • Tissue Augmentation
  • Needle Coating
  • Stent Coating
  • Trocar Coating
  • Mesh Coating
  • Fiber Coatings

The most remarkable characteristics of these polymers are:

 

  • High Strength
  • Tailored bioavailability
  • Broad range of physical state: Liquid to semi crystalline to crystalline
  • Unique combination of lipophilic and hydrophilic functions
  • Water soluble
  • Absorbable/Hydrolysable
  • Excellent heat stability

Polyoxaester Patent List

1. Rao S. Bezwada, Dennis D. Jamiolkowski. Absorbable
polyoxaesters. U S Patent No.5,464,929 (1995).
2. Rao S. Bezwada, Dennis D. Jamiolkowski Absorbable
polyoxaesters containing amines and/or amido groups. U S Patent
No. 5,595,751 (1995).
3. Rao S. Bezwada, Dennis D. Jamiolkowski Blends of absorbable
polyoxaamides U S Patent No. 5,597,579 (1997).
4. Rao S. Bezwada, Dennis D. Jamiolkowski Polymer blends
containing absorbable polyoxaesters US Patent No. 5,607,687
(1997).
5. Rao S. Bezwada, Dennis D. Jamiolkowski, Absorbable
polyoxaesters US Patent No. 5,618,552 (1997).
6. Rao S. Bezwada, Dennis D. Jamiolkowski Blends of absorbable
polyoxaesters containing amines and/or amido groups. U S Patent
No.5,620,698 (1997).
7. Kevin Cooper , Angelo Scopelianos. Absorbable polyalkylene
diglycolates. U S Patent No. 5,644,002 (1997).
8. Rao S. Bezwada, Dennis D. Jamiolkowski Blending containing
absorbable polyoxaamides U S Patent No.5,645,850 (1997).
9. Rao S. Bezwada, Dennis D. Jamiolkowski Blends of absorbable
polyoxaesters containing amines and/or amide groups US Patent
No.5,648,088 (1997).
10. Kevin Cooper, Angelo G. Scopelianos. Absorbable polyalkylene
diglycolates. U S Patent No.5,688,900 (1997).
11. Kevin Cooper, Angelo Scopelianos. Absorbable polyalkylene
diglycolates US Patent No. 5,696,178 (1997).
12. Dennis D. Jamiolkowski, Rao S. Bezwada. Hydrogels of
absorbable polyoxaesters. US Patent No.5,698,213 (1997).
13. Dennis D. Jamiolkowski, Rao S. Bezwada. Hydrogels of absorbable
polyoxaesters containing amines or amido groups. US Patent
No.5,700,583 (1997).
14. Kevin Cooper, Angelo Scopelianos. Absorbable polyalkylene
diglycolates. U S Patent No. 5,736,589 (1998).
15. Dennis D. Jamiolkowski, Rao S. Bezwada. Prepolymers of
absorbable polyoxaesters containing amines and/or amido
groups. S Patent No.5,844,017 (1998).
16. Dennis D. Jamiolkowski, Rao S. Bezwada. Prepolymers of
absorbable polyoxaesters. U S Patent No.5,859,150 (1999).
17. Dennis D. Jamiolkowski, Rao S. Bezwada,. Hydrogels containing
absorbable polyoxaamides. US Patent No.5,962,023 (1999).
18. Dennis D. Jamiolkowski, Rao S. Bezwada. Absorbable
polyoxaesters containing amines and/ or amido groups. US Patent
No. 6,074,660 (2000).
19. Dennis D. Jamiolkowski, Rao S. Bezwada. Copolymers of absorbable
polyoxaesters. US Patent No. 6,224,894 (2001).
20. Dennis D. Jamiolkowski, Rao S. Bezwada. Hydrogels containing
absorbable polyoxaamides. S Patent No. 6,251,435 (2001).
21. Rao S. Bezwada, Dennis D. Jamiolkowski. Hydrogels containing
absorbable polyoxaamides. S Patent No. 6,372,256 (2002).
22. Dennis D. Jamiolkowski, Rao S. Bezwada. Hydrogels containing
absorbable polyoxaamides. S Patent No. 6,458,385 (2002).
23. Sasa Andjelic. Absorbable copolyesters of poly(ethoxyethylene
diglycolate) and glycolide. U S Patent No.7,652,127 (2010).
24. Sasa Andjelic, Rao S. Bezwada, Dennis D. Jamiolkowski. Method of
preventing post-operative surgical adhesion. U S Patent No.
7,754,233 (2010).
25. Sasa Andjelic. Absorbable copolyesters of poly(ethoxyethylene
diglycolate) and glycolide. U S Patent No.7,861,27 (2006).
26. Sasa Andjelic et al. Absorbable copolyesters of poly(ethoxyethylene
diglycolate) and glycolide. U S Patent No. 7,968,656 (2011).
27. Rao S. Bezwada. Hydrolysable linkers and cross-linkers for absorbable
polymers. U S Patent No. US 8,048,980 (2011).
28. Catherine Manya Rohloff et al. Polyoxaester suspending vehicles for
use with implantable delivery systems. US Patent No. 8,114,430
(2012).
29. Rao S. Bezwada. Controlled release of biologically active compounds
US Patent No. 8,217,134 (2012).
30. Sasa Andjelic. Composite layered hemostasis device U S Patent No.
8,349,354 (2013).
31. Sasa Andjelic, Tara Zabrosky. Absorbable polymer formulations. U S
Patent No. 8,440,215 (2013).
32. Rao S. Bezwada. Hydrolysable linkers and cross-linkers for absorbable
polymers. U S Patent No. US 8,664,429 (2014).
33. Sasa Andjelic, Joerg PRIEWE. Absorbable polyethylene diglycolate
copolymers to reduce microbial adhesion to medical devices and
implants U S Patent No.9,044,524 (2015).
34. Rao S. Bezwada. Hydrolysable linkers and cross-linkers for absorbable
polymers. U S Patent No. 9,174,924 (2015).
35. Sasa Andjelic. Semi-crystalline, fast absorbing polymer formulation. U
S Patent No. 9,200,112.
36. Ankur S. Kulshrestha, Kevin Cooper, Walter R. Laredo. Absorbable
polyoxaesters containing pendant functional groups. US Patent
No.2007/0225452 (2007).
37. Sasa Andjelic, Dennis D. Jamiolkowski and Rao Bezwada
Polyoxaesters” Polymer International 56:1063-1077 (2007).
38. Sasa Andjelic, et al. Hydrophilic absorbable copolyester exhibiting
zero order drug release Pharmaceutical Research, Vol 23, No.4 April
2006.

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