Polyoxaesters
A new class of hydrophilic absorbable polyesters called polyoxaesters is an excellent choice for a broad range of biomedical applications.
Polyoxaester development is based on aliphatic diacids possessing oxygen atoms adjacent to their α-carbons. These diacids are then polymerized in conjunction with a diol by means of a polycondensation reaction. Since organic chemists have used the term ‘oxa’ to designate the replacement of an ethylene group by an oxygen atom, these diacids have been called oxadiacids, and the resulting polymers polyoxaesters.
Strategic placement of glycolic acid moieties in the polymeric chains allow control of their hydrophobic/hydrophilic properties and of their degradation/absorption rate. Fully controllable hydrolysis and degradation profiles can be obtained by using a combination of difunctionalized aromatic compounds, such as the blend of two or more functionalized compounds made from any two or more of the glycolide, lactide, dioxanone, and polydioxanone species combined with one aromatic compound.
To learn more about polyoxaesters, view a presentation or read a mini-review article published in Polymer International.
Range of Applications
- Suture Material
- Mesh
- Absorbable Elastomer
- Adhesion Prevention
- Sealants & Adhesives
- Drug Delivery
- Wound Coverings
- Tissue Sealants & Adhesives
- Tissue Engineering
- Tissue Augmentation
- Needle Coating
- Stent Coating
- Trocar Coating
- Mesh Coating
- Fiber Coatings
The most remarkable characteristics of these polymers are:
- High Strength
- Tailored bioavailability
- Broad range of physical state: Liquid to semi crystalline to crystalline
- Unique combination of lipophilic and hydrophilic functions
- Water soluble
- Absorbable/Hydrolysable
- Excellent heat stability
Polyoxaester Patent List
Polymers
Applications
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