Polyoxaesters

A new class of hydrophilic absorbable polyesters called polyoxaesters is an excellent choice for a broad range of biomedical applications.

Polyoxaester development is based on aliphatic diacids possessing oxygen atoms adjacent to their α-carbons. These diacids are then polymerized in conjunction with a diol by means of a polycondensation reaction. Since organic chemists have used the term ‘oxa’ to designate the replacement of an ethylene group by an oxygen atom, these diacids have been called oxadiacids, and the resulting polymers polyoxaesters.

Strategic placement of glycolic acid moieties in the polymeric chains allow control of their hydrophobic/hydrophilic properties and of their degradation/absorption rate. Fully controllable hydrolysis and degradation profiles can be obtained by using a combination of difunctionalized aromatic compounds, such as the blend of two or more functionalized compounds made from any two or more of the glycolide, lactide, dioxanone, and polydioxanone species combined with one aromatic compound.

To learn more about polyoxaesters, view a presentation or read a mini-review article published in Polymer International.

Range of Applications

Suture Material
Mesh
Absorbable Elastomer
Adhesion Prevention
Sealants & Adhesives
Drug Delivery
Wound Coverings
Tissue Sealants & Adhesives
Tissue Engineering
Tissue Augmentation
Needle Coating
Stent Coating
Trocar Coating
Mesh Coating
Fiber Coatings

The most remarkable characteristics of these polymers are:

High Strength
Tailored bioavailability
Broad range of physical state: Liquid to semi crystalline to crystalline
Unique combination of lipophilic and hydrophilic functions
Water soluble
Absorbable/Hydrolysable
Excellent heat stability

Polyoxaesters_Bezwada_Presentation

Polyoxaester Patent List

1. Rao S. Bezwada, Dennis D. Jamiolkowski. Absorbable polyoxaesters. U S Patent No.5,464,929 (1995). 2. Rao S. Bezwada, Dennis D. Jamiolkowski Absorbable polyoxaesters containing amines and/or amido groups. U S Patent No. 5,595,751 (1995). 3. Rao S. Bezwada, Dennis D. Jamiolkowski Blends of absorbable polyoxaamides U S Patent No. 5,597,579 (1997). 4. Rao S. Bezwada, Dennis D. Jamiolkowski Polymer blends containing absorbable polyoxaesters US Patent No. 5,607,687 (1997). 5. Rao S. Bezwada, Dennis D. Jamiolkowski, Absorbable polyoxaesters US Patent No. 5,618,552 (1997). 6. Rao S. Bezwada, Dennis D. Jamiolkowski Blends of absorbable polyoxaesters containing amines and/or amido groups. U S Patent No.5,620,698 (1997). 7. Kevin Cooper , Angelo Scopelianos. Absorbable polyalkylene diglycolates. U S Patent No. 5,644,002 (1997). 8. Rao S. Bezwada, Dennis D. Jamiolkowski Blending containing absorbable polyoxaamides U S Patent No.5,645,850 (1997). 9. Rao S. Bezwada, Dennis D. Jamiolkowski Blends of absorbable polyoxaesters containing amines and/or amide groups US Patent No.5,648,088 (1997). 10. Kevin Cooper, Angelo G. Scopelianos. Absorbable polyalkylene diglycolates. U S Patent No.5,688,900 (1997). 11. Kevin Cooper, Angelo Scopelianos. Absorbable polyalkylene diglycolates US Patent No. 5,696,178 (1997). 12. Dennis D. Jamiolkowski, Rao S. Bezwada. Hydrogels of absorbable polyoxaesters. US Patent No.5,698,213 (1997). 13. Dennis D. Jamiolkowski, Rao S. Bezwada. Hydrogels of absorbable polyoxaesters containing amines or amido groups. US Patent No.5,700,583 (1997). 14. Kevin Cooper, Angelo Scopelianos. Absorbable polyalkylene diglycolates. U S Patent No. 5,736,589 (1998). 15. Dennis D. Jamiolkowski, Rao S. Bezwada. Prepolymers of absorbable polyoxaesters containing amines and/or amido groups. S Patent No.5,844,017 (1998). 16. Dennis D. Jamiolkowski, Rao S. Bezwada. Prepolymers of absorbable polyoxaesters. U S Patent No.5,859,150 (1999). 17. Dennis D. Jamiolkowski, Rao S. Bezwada,. Hydrogels containing absorbable polyoxaamides. US Patent No.5,962,023 (1999).

18. Dennis D. Jamiolkowski, Rao S. Bezwada. Absorbable polyoxaesters containing amines and/ or amido groups. US Patent No. 6,074,660 (2000). 19. Dennis D. Jamiolkowski, Rao S. Bezwada. Copolymers of absorbable polyoxaesters. US Patent No. 6,224,894 (2001). 20. Dennis D. Jamiolkowski, Rao S. Bezwada. Hydrogels containing absorbable polyoxaamides. S Patent No. 6,251,435 (2001). 21. Rao S. Bezwada, Dennis D. Jamiolkowski. Hydrogels containing absorbable polyoxaamides. S Patent No. 6,372,256 (2002). 22. Dennis D. Jamiolkowski, Rao S. Bezwada. Hydrogels containing absorbable polyoxaamides. S Patent No. 6,458,385 (2002). 23. Sasa Andjelic. Absorbable copolyesters of poly(ethoxyethylene diglycolate) and glycolide. U S Patent No.7,652,127 (2010). 24. Sasa Andjelic, Rao S. Bezwada, Dennis D. Jamiolkowski. Method of preventing post-operative surgical adhesion. U S Patent No. 7,754,233 (2010). 25. Sasa Andjelic. Absorbable copolyesters of poly(ethoxyethylene diglycolate) and glycolide. U S Patent No.7,861,27 (2006). 26. Sasa Andjelic et al. Absorbable copolyesters of poly(ethoxyethylene diglycolate) and glycolide. U S Patent No. 7,968,656 (2011). 27. Rao S. Bezwada. Hydrolysable linkers and cross-linkers for absorbable polymers. U S Patent No. US 8,048,980 (2011). 28. Catherine Manya Rohloff et al. Polyoxaester suspending vehicles for use with implantable delivery systems. US Patent No. 8,114,430 (2012). 29. Rao S. Bezwada. Controlled release of biologically active compounds US Patent No. 8,217,134 (2012). 30. Sasa Andjelic. Composite layered hemostasis device U S Patent No. 8,349,354 (2013). 31. Sasa Andjelic, Tara Zabrosky. Absorbable polymer formulations. U S Patent No. 8,440,215 (2013). 32. Rao S. Bezwada. Hydrolysable linkers and cross-linkers for absorbable polymers. U S Patent No. US 8,664,429 (2014). 33. Sasa Andjelic, Joerg PRIEWE. Absorbable polyethylene diglycolate copolymers to reduce microbial adhesion to medical devices and implants U S Patent No.9,044,524 (2015). 34. Rao S. Bezwada. Hydrolysable linkers and cross-linkers for absorbable polymers. U S Patent No. 9,174,924 (2015). 35. Sasa Andjelic. Semi-crystalline, fast absorbing polymer formulation. U S Patent No. 9,200,112. 36. Ankur S. Kulshrestha, Kevin Cooper, Walter R. Laredo. Absorbable polyoxaesters containing pendant functional groups. US Patent No.2007/0225452 (2007). 37. Sasa Andjelic, Dennis D. Jamiolkowski and Rao Bezwada Polyoxaesters” Polymer International 56:1063-1077 (2007). 38. Sasa Andjelic, et al. Hydrophilic absorbable copolyester exhibiting zero order drug release Pharmaceutical Research, Vol 23, No.4 April 2006.