Technology

The novel and proprietary family of biodegradable polymers developed by Bezwada Biomedical can be classified into the following technology platforms:

ABSORBABLE POLYURETHANES

Key Attributes

  • Derived from hydrolytically degradable isocyanates
  • Tunable physical, mechanical properties and hydrolytic degradation profile
  • Releases safe and biocompatible molecules upon degradation

Applications

  • Wound healing
  • Tissue Engineering
  • Coatings
  • Drug delivery

Patents

  • 8,551,519 Bioabsorbable surgical articles or components thereof
  •  8,367,747 Bioabsorbable polymers from bioabsorbable polyisocyanates and uses thereof
  • 8,143,325 Bioabsorbable and biocompatible polyurethanes and polyamides for medical devices
  • 7,772,352 Bioabsorbable and biocompatible polyurethanes and polyamides for medical devices
  • 8,846,845 Bioabsorbable and biocompatible polyurethanes and polyamides for medical devices

  • 8,901,347 Absorbable polyurethanes and methods of use thereof
  • EP2298235B1 Bioabsobable and biocompatible polyurethanes and polyamides for medical devices
  • EP1937182B1 Bioabsobable and biocompatible polyurethanes and polyamides for medical devices
  • 9,328,192 Bio-based monomers and polymers

ABSORBABLE POLYMERS FROM FUNCTIONALIZED DRUGS

Key Attributes

  • Derived from drugs and safe and biocompatible molecules
  • Tunable hydrolytic degradation profile
  • Releases drug molecule as such along with safe and biocompatible molecules upon degradation

Applications

  • Controlled drug delivery
  • Pain management
  • Wound healing

Patents

  • 8,802,147 Controlled release of biologically active compounds
  • 8,552,139 Controlled release of biologically active compounds
  • 8,409,559 Functionalized drugs and polymers derived therefrom
  • 8,217,134 Controlled release of biologically active compounds

  • 8,163,806 Controlled release of biologically active compounds from multiarmed oligomers
  • 8,026,285 Control release of biologically active compounds from multi-armed oligomers
  • 7,691,364 Functionalized drugs and polymers derived therefrom
    RE45, 548 Functionalized drugs and polymers derived therefrom

ANTIMICROBIALS

Key Attributes

  • Based on functionalized Triclosan
  • Controllable release of Triclosan molecules along with safe and biocompatible molecules

Applications

  • Antimicrobial coatings
  • Antimicrobial formulations

Patents

  • 8,399,696 Functionalized biodegradable triclosan monomers and oligomers for controlled release
  • 8,232,422 Functionalized biodegradable triclosan monomers and oligomers for controlled release
  • 8,053,591 Functionalized biodegradable triclosan monomers and oligomers for controlled release

NITRIC-OXIDE-RELEASING DRUGS

Key Attributes

  • Drug molecules and NO releasing moiety attached via hydrolytically degradable linker
  • Controllable release profiles

Applications

  • Treatment of Glaucoma, Osteoarthritis, Cardio-metabolic and inflammatory disorders
  • NO releasing coatings

Patents

  • 8,303,978 Controlled release of nitric oxide and drugs from functionalized macromers and oligomers
  • 8,062,653 Controlled release of nitric oxide and drugs from functionalized macromers and oligomers
  • EP2398761A2 Controlled release of nitric oxide and drugs from functionalized macromers and oligomers

ABSORBABLE POLYMERS FROM FUNCTIONALIZED PHENOLICS & NATURAL PRODUCTS

Key Attributes

  • Derived from natural phenolic molecules such as flavonoids, chalcones and coumarins
  • Incorporates beneficial attributes of natural molecules in the polymer backbone
  • Tunable hydrolytic degradation profiles

Applications

  • Drug delivery
  • Cosmetics
  • Radiation-stable medical devices
  • Anti-microbial coatings

Patents

  • 8,802,892 Functionalized phenolic compounds and polymers therefrom
  • 8,372,882 Functionalized phenolic esters and amides and polymers therefrom
  • 8,318,973 Functionalized sinapic acid and methyl sinapate
  • 8,309,132 Bioabsorbable polyesteramides and uses thereof
  • 8,048,980 Hydrolysable linkers and cross-linkers for absorbable polymers
  • 8,007,526 Difunctionalized aromatic compounds and polymers therefrom

  • 7,902,319 Unsymmetrical aromatic ether diacids and absorbable polymers therefrom
  • 7,85,8077 Functionalized phenolic esters and amides and polymers therefrom
  • 7,671,168 Unsymmetrical aromatic ether diacids and absorbable polymers therefrom
  • 8,664,429 Hydrolysable linkers and cross-linkers for absorbable polymers
  • 9,045,396 Hydrolysable linkers and cross-linkers for absorbable polymers
  • 9,174,924 Hydrolysable linkers and cross-linkers for absorbable polymers

ABSORBABLE POLYMERS FROM FUNCTIONALIZED AMINO ACIDS

Key Attributes

  • Derived from amino acids functionalized with safe and biocompatible molecules
  • Tunable physical, mechanical properties and hydrolytic degradation profile
  • Releases safe and biocompatible molecules upon degradation

Applications

  • Drug Delivery
  • Stent and Stent Coatings
  • Scaffolds

Patents

  • 8,754,135 Functionalized non-phenolic amino acids and absorbable polymers therefrom
  • 8,519,175 Functionalized amino acids and absorbable polymers therefrom
  • 8,519,156 Functionalized non-phenolic amino acids and absorbable polymers therefrom
  • 8,461,372 Amino acid derivatives and absorbable polymers therefrom
  • 8,436,201 Functionalized diphenolics and absorbable polymers therefrom
  • 8,367,108 Functionalized non-phenolic amino acids and absorbable polymers therefrom
  • 8,309,754 Functionalized amino acids and absorbable polymers therefrom

  • 8,288,505 Functionalized diphenolics and absorbable polymers therefrom
  • 8,093,420 Functionalized amino acids and absorbable polymers therefrom
  • 7,935,843 Functionalized diphenolics and absorbable polymers therefrom
  • 8,664,426 Functionalized amino acids and absorbable polymers therefrom
  • 8,901,341 Amino acid derivatives and absorbable polymers therefrom
  • 9,012,677 Amino acid derivatives and absorbable polymers therefrom
  • EP19487113B2 Functionalized amino acids and bioabsorbable polymers therefrom

Each of these technology platforms can be used to generate products with a wide range of therapeutic applications.
The polymers will find applications in:

  • Tissue Adhesives and Sealants
  • Medical Devices
  • Drug delivery and wound care
  • Tissue engineering

Key Attributes of our Platforms

  • Bioabsorbable/Biocompatible/Biodegradable
  • Derived from monomers prepared by functionalization of natural products, amino acids and drug molecules of interest with safe and biocompatible building blocks including glycolic, lactic acid, caprolactone and p-dioxanone.
  • Can be tailored for specific end use applications
  • Chemistry used to synthesize monomers and polymers is simple and economical.

Advantages of our Technology over Prior Art

  • Controlled degradation profiles
  • Tunable physical and mechanical properties
  • Derived from safe and biocompatible molecules
  • Degradation products safe and biocompatible
  • Bioactive molecule remains unaffected
  • Enhance Bioavailability of Drugs
  • Increased circulation time of drug

Capabilities

  • UV-Visible Spectroscopy
  • Infrared Spectroscopy
  • GC
  • HPLC
  • TLC

  • Karl Fischer
  • Differential Scanning Calorimetry
  • Solution Viscometry
  • Gel Permeation Chromatography

Pilot Plant Facilities

  • 10 Gallons to 50 Gallons
  • Production Units:
  • 55 gallons to 500 gallons